Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury
推荐理由
早期的动物实验验证闭环调控步态的可行性和优势，通过对刺激频率的调整影响大鼠行走过程中的步态，减少疲劳，修正步态，完成上台阶等运动。其中闭环框架以及文章涉及的叙事逻辑值得学习
| 文章简介 | |
|---|---|
| 期刊 | Science translational medicine |
| 发表年份 | 2014 |
| DOI | 10.1126/scitranslmed.3008325 |
| 类型 | 研究性工作 |
| 领域 | 动物实验研究 |
| 引用量 | {{{Citation_}}} |
| 推荐信息 | |
|---|---|
| 推荐人 | 张熹 |
| 审核 | 马伯志、张博扬 |
| 推荐小组 | 人工脊髓小组 |
摘要
Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We developed a mechanistic framework to optimize neuromodulation in real time to achieve high-fidelity control of leg kinematics during locomotion in rats. We first uncovered relationships between neuromodulation parameters and recruitment of distinct sensorimotor circuits, resulting in predictive adjustments of leg kinematics. Second, we established a technological platform with embedded control policies that integrated robust movement feedback and feed-forward control loops in real time. These developments allowed us to conceive a neuroprosthetic system that controlled a broad range of foot trajectories during continuous locomotion in paralyzed rats. Animals with complete spinal cord injury performed more than 1000 successive steps without failure, and were able to climb staircases of various heights and lengths with precision and fluidity. Beyond therapeutic potential, these findings provide a conceptual and technical framework to personalize neuromodulation treatments for other neurological disorders.
细分领域