An implantable ultrasound-powered device for the treatment of brain cancer using electromagnetic fields
推荐理由
介绍了一种可植入的通过无线超声供电的柔性电极，可用于TTF治疗
| 文章简介 | |
|---|---|
| 期刊 | SCIENCE ADVANCES |
| 发表年份 | 2022 |
| DOI | 10.1126/sciadv.abm5023 |
| 类型 | 研究性工作 |
| 领域 | 植入式电极 |
| 引用量 | 13 |
| 推荐信息 | |
|---|---|
| 推荐人 | 杨鑫 |
| 审核 | 胡春华 |
| 推荐小组 | TTF小组 |
摘要
Brain tumors have been proved challenging to treat. Here, we present a promising alternative by developing an implantable ultrasound-powered tumor treating device (UP-TTD) that electromagnetically disrupts the rapid division of cancer cells without any adverse effects on normal neurons, thereby safely inhibiting brain cancer recurrence. In vitro and in vivo experiments confirmed the significant therapeutic effect of the UP-TTD, with ~58% inhibition on growth rate of clinical tumor cells and ~78% reduction of cancer area in tumor-bearing rats. This UP-TTD is wireless ultrasound-powered, chip-sized, lightweight, and easy to operate on complex surfaces, with a largely boosting therapeutic efficiency and reducing energy consumption. Meanwhile, various treatment parameters could be tuned from the UP-TTD without increasing its size or adding circuits on the integrated chip. The tuning process was simulated and discussed, showing an excellent agreement with the experimental data. The encouraging results of the UP-TTD raise the possibility of a new modality for brain cancer treatment.
细分领域
< | 超声、柔性电极