Long-term wireless streaming of neural recordings for circuit discovery and adaptive stimulation in individuals with Parkinson’s disease
推荐理由
长期闭环研究的典型范式之一，通过对五名患者的十五个月长期随访数据，系统评估了长期条件下闭环实现的可行性和价值，提出并验证了可实现的控制策略和反馈机制。
| 文章简介 | |
|---|---|
| 期刊 | Nature Biotechnology |
| 发表年份 | 2021 |
| DOI | 10.1038/s41587-021-00897-5 |
| 类型 | 研究性工作 |
| 领域 | 神经调控治疗 |
| 引用量 | 184 |
| 推荐信息 | |
|---|---|
| 推荐人 | 樊钰 |
| 审核 | 於慧龄 |
| 推荐小组 | PD-闭环小组 |
摘要
Neural recordings using invasive devices in humans can elucidate the circuits underlying brain disorders, but have so far been limited to short recordings from externalized brain leads in a hospital setting or from implanted sensing devices that provide only intermittent, brief streaming of time series data. Here, we report the use of an implantable two-way neural interface for wireless, multichannel streaming of field potentials in five individuals with Parkinson’s disease (PD) for up to 15 months after implantation. Bilateral four-channel motor cortex and basal ganglia field potentials streamed at home for over 2,600 h were paired with behavioral data from wearable monitors for the neural decoding of states of inadequate or excessive movement. We validated individual-specific neurophysiological biomarkers during normal daily activities and used those patterns for adaptive deep brain stimulation (DBS). This technological approach may be widely applicable to brain disorders treatable by invasive neuromodulation.
细分领域