Tumour treating fields therapy for glioblastoma: current advances and future directions

推荐理由

比较全面地介绍了TTF疗法近20年的发展历史，包括其机制研究、临床研究、现实应用等多方面的情况

文章简介
期刊	British Journal of Cancer
发表年份	2020
DOI	10.1038/s41416-020-01136-5
类型	综述
领域	TTF疗法的发展历程
引用量	{{{Citation_}}}

推荐信息
推荐人	杨鑫
审核	胡春华
推荐小组	TTF小组

摘要

Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and continues to portend poor survival, despite multimodal treatment using surgery and chemoradiotherapy. The addition of tumour-treating fields (TTFields)—an approach in which alternating electrical fields exert biophysical force on charged and polarisable molecules known as dipoles—to standard therapy, has been shown to extend survival for patients with newly diagnosed GBM, recurrent GBM and mesothelioma, leading to the clinical approval of this approach by the FDA. TTFields represent a non-invasive anticancer modality consisting of low-intensity (1–3 V/cm), intermediate-frequency (100–300 kHz), alternating electric fields delivered via cutaneous transducer arrays configured to provide optimal tumour-site coverage. Although TTFields were initially demonstrated to inhibit cancer cell proliferation by interfering with mitotic apparatus, it is becoming increasingly clear that TTFields show a broad mechanism of action by disrupting a multitude of biological processes, including DNA repair, cell permeability and immunological responses, to elicit therapeutic effects. This review describes advances in our current understanding of the mechanisms by which TTFields mediate anticancer effects. Additionally, we summarise the landscape of TTFields clinical trials across various cancers and consider how emerging preclinical data might inform future clinical applications for TTFields.

细分领域

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