Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumors
推荐理由
系统性地介绍了关于TTF疗法的细胞实验、动物实验及临床实验的方法及实验结果
| 文章简介 | |
|---|---|
| 期刊 | PNAS |
| 发表年份 | 2007 |
| DOI | 10.1073/pnas.0702916104 |
| 类型 | 研究性工作 |
| 领域 | 肿瘤治疗电场 |
| 引用量 | {{{Citation_}}} |
| 推荐信息 | |
|---|---|
| 推荐人 | 杨鑫 |
| 审核 | 胡春华 |
| 推荐小组 | TTF小组 |
摘要
We have recently shown that low intensity, intermediate frequency, electric fields inhibit by an anti-microtubule mechanism of action, cancerous cell growth in vitro. Using implanted electrodes, these fields were also shown to inhibit the growth of dermal tumors in mice. The present study extends these findings to additional cell lines [human breast carcinoma; MDA-MB-231, and human non-small-cell lung carcinoma (H1299)] and to animal tumor models (intradermal B16F1 melanoma and intracranial F-98 glioma) using external insulated electrodes. These findings led to the initiation of a pilot clinical trial of the effects of TTFields in 10 patients with recurrent glioblastoma (GBM). Median time to disease progression in these patients was 26.1 weeks and median overall survival was 62.2 weeks. These time to disease progression and OS values are more than double the reported medians of historical control patients. No device-related serious adverse events were seen after >70 months of cumulative treatment in all of the patients. The only device-related side effect seen was a mild to moderate contact dermatitis beneath the field delivering electrodes. We conclude that TTFields are a safe and effective new treatment modality which effectively slows down tumor growth in vitro, in vivo and, as demonstrated here, in human cancer patients.
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