Diurnal modulation of subthalamic beta oscillatory power in Parkinson’s disease patients during deep brain stimulation
推荐理由
该工作通过11名被试的长期（34±13.4 days）持续性STN-LFP记录发现了beta频段的昼夜节律，此外，对日间的运动对beta影响进行了探究。该项工作首次探究了STN-LFP的beta活动在24小时周期的节律变化，并对闭环DBS的调控策略带来启发。
| 文章简介 | |
|---|---|
| 期刊 | npj Parkinson s Disease |
| 发表年份 | 2022 |
| DOI | 10.1038/s41531-022-00350-7 |
| 类型 | 研究性工作 |
| 领域 | 神经调控治疗 |
| 引用量 | {{{Citation_}}} |
| 推荐信息 | |
|---|---|
| 推荐人 | 关凌霄 |
| 审核 | 於慧龄 |
| 推荐小组 | PD-闭环小组 |
摘要
Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson's disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS). While beta fluctuations in PD patients are well characterized on shorter timescales, it is not known how beta activity evolves around the diurnal cycle, outside a clinical setting. Here, we obtained chronic recordings (34 ± 13 days) of subthalamic beta power in PD patients implanted with the Percept DBS device during high-frequency DBS and analysed their diurnal properties as well as sensitivity to artifacts. Time of day explained 41 ± 9% of the variance in beta power (p < 0.001 in all patients), with increased beta during the day and reduced beta at night. Certain movements affected LFP quality, which may have contributed to diurnal patterns in some patients. Future DBS algorithms may benefit from taking such diurnal and artifactual fluctuations in beta power into account.
细分领域