Beta activity in the subthalamic nucleus during sleep in patients with Parkinson's disease
推荐理由
帕金森病患者睡眠分期相关STN-LFPs的首个临床研究。该文章主要发现了beta活动在进入N2及慢波睡眠后的显著降低但在REM期维持较高水平，并同步探究了睡眠中STN与皮层电生理的相干性关系，为STN参与睡眠活动及相应的DBS刺激策略提供了依据。
| 文章简介 | |
|---|---|
| 期刊 | Movement Disorders |
| 发表年份 | 2009 |
| DOI | 10.1002/mds.22351 |
| 类型 | 研究性工作 |
| 领域 | 睡眠电生理 |
| 引用量 | 68 |
| 推荐信息 | |
|---|---|
| 推荐人 | 张国坤 |
| 审核 | 於慧龄 |
| 推荐小组 | PD-闭环小组 |
摘要
The recordings of local field potentials in the subthalamic nucleus in patients with Parkinson's disease (PD), carried out through the stimulators implanted to treat the motor symptoms of the disease, show a prominent basal ("off") activity in the beta range, which is attenuated after dopaminergic therapy. A recent study described improvement of parkinsonian features during rapid eyes movements (REM) sleep. We describe, for the first time, the changes in activity of the subthlamic nucleus (STN) during different sleep stages in Parkinson's disease with special interest in the beta band. Ten patients with PD treated with deep brain stimulation of the STN were studied. Subthalamic local field potentials (LFPs) were recorded through the stimulation electrodes during wakefulness ("off" medication) and different sleep stages. In Stage 2 and slow-wave sleep, a significant decrease of beta activity was recorded. During REM sleep, beta power values were similar to wakefulness values or even higher. These findings indicate that STN activity is modulated and modified during different sleep stages. The increased beta activity during REM sleep is a new but unexpected finding, which requires further analysis.
细分领域