人工脊髓小组/人类临床研究/Compound action potentials recorded in the human spinal cord during neurostimulation for pain relief：修订间差异
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{{文章推荐|Reason=临床人体体内诱发复合动作电位(evoked compound action potential, ECAP)采集的报道，探索了ECAP信号随刺激参数变化的规律，并提出了关于SCS抑制疼痛的机制假说，是ECAP领域内研究都会参考的工作。|Journal=Pain|PubYear=2012|DOI=10.1016/j.pain.2011.11.023|Category_=研究性工作|Domain=人类临床研究|RecomBy=张皓晨|RecomGrp=人工脊髓小组|ReviewBy=马伯志、张博扬|Abstract=Electrical stimulation of the spinal cord provides effective pain relief to hundreds of thousands of chronic neuropathic pain sufferers. The therapy involves implantation of an electrode array into the epidural space of the subject and then stimulation of the dorsal column with electrical pulses. The stimulation depolarises axons and generates propagating action potentials that interfere with the perception of pain. Despite the long-term clinical experience with spinal cord stimulation, the mechanism of action is not understood, and no direct evidence of the properties of neurons being stimulated has been presented. Here we report novel measurements of evoked compound action potentials from the spinal cords of patients undergoing stimulation for pain relief. The results reveal that Ab sensory nerve fibres are recruited at therapeutic stimulation levels and the Ab potential amplitude correlates with the degree of coverage of the painful area. Ab-evoked responses are not measurable below a threshold stimulation level, and their amplitude increases with increasing stimulation current. At high currents, additional late responses are observed. Our results contribute towards efforts to define the mechanism of spinal cord stimulation. The minimally invasive recording technique we have developed provides data previously obtained only through microelectrode techniques in spinal cords of animals. Our observations also allow the development of systems that use neuronal recording in a feedback loop to control neurostimulation on a continuous basis and deliver more effective pain relief. This is one of numerous benefits that in vivo electrophysiological recording can bring to a broad range of neuromodulation therapies.|DetaialsDM=闭环调控-电诱发复合动作电位研究}} | {{文章推荐|Reason=临床人体体内诱发复合动作电位(evoked compound action potential, ECAP)采集的报道，探索了ECAP信号随刺激参数变化的规律，并提出了关于SCS抑制疼痛的机制假说，是ECAP领域内研究都会参考的工作。|Journal=Pain|PubYear=2012|DOI=10.1016/j.pain.2011.11.023|Category_=研究性工作|Domain=人类临床研究|RecomBy=张皓晨|RecomGrp=人工脊髓小组|ReviewBy=马伯志、张博扬|Abstract=Electrical stimulation of the spinal cord provides effective pain relief to hundreds of thousands of chronic neuropathic pain sufferers. The therapy involves implantation of an electrode array into the epidural space of the subject and then stimulation of the dorsal column with electrical pulses. The stimulation depolarises axons and generates propagating action potentials that interfere with the perception of pain. Despite the long-term clinical experience with spinal cord stimulation, the mechanism of action is not understood, and no direct evidence of the properties of neurons being stimulated has been presented. Here we report novel measurements of evoked compound action potentials from the spinal cords of patients undergoing stimulation for pain relief. The results reveal that Ab sensory nerve fibres are recruited at therapeutic stimulation levels and the Ab potential amplitude correlates with the degree of coverage of the painful area. Ab-evoked responses are not measurable below a threshold stimulation level, and their amplitude increases with increasing stimulation current. At high currents, additional late responses are observed. Our results contribute towards efforts to define the mechanism of spinal cord stimulation. The minimally invasive recording technique we have developed provides data previously obtained only through microelectrode techniques in spinal cords of animals. Our observations also allow the development of systems that use neuronal recording in a feedback loop to control neurostimulation on a continuous basis and deliver more effective pain relief. This is one of numerous benefits that in vivo electrophysiological recording can bring to a broad range of neuromodulation therapies.|DetaialsDM=闭环调控-电诱发复合动作电位研究|Citation_=132}} | ||
2024年1月18日 (四) 22:39的版本
推荐理由
临床人体体内诱发复合动作电位(evoked compound action potential, ECAP)采集的报道，探索了ECAP信号随刺激参数变化的规律，并提出了关于SCS抑制疼痛的机制假说，是ECAP领域内研究都会参考的工作。
| 文章简介 | |
|---|---|
| 期刊 | Pain |
| 发表年份 | 2012 |
| DOI | 10.1016/j.pain.2011.11.023 |
| 类型 | 研究性工作 |
| 领域 | 人类临床研究 |
| 引用量 | 132 |
| 推荐信息 | |
|---|---|
| 推荐人 | 张皓晨 |
| 审核 | 马伯志、张博扬 |
| 推荐小组 | 人工脊髓小组 |
摘要
Electrical stimulation of the spinal cord provides effective pain relief to hundreds of thousands of chronic neuropathic pain sufferers. The therapy involves implantation of an electrode array into the epidural space of the subject and then stimulation of the dorsal column with electrical pulses. The stimulation depolarises axons and generates propagating action potentials that interfere with the perception of pain. Despite the long-term clinical experience with spinal cord stimulation, the mechanism of action is not understood, and no direct evidence of the properties of neurons being stimulated has been presented. Here we report novel measurements of evoked compound action potentials from the spinal cords of patients undergoing stimulation for pain relief. The results reveal that Ab sensory nerve fibres are recruited at therapeutic stimulation levels and the Ab potential amplitude correlates with the degree of coverage of the painful area. Ab-evoked responses are not measurable below a threshold stimulation level, and their amplitude increases with increasing stimulation current. At high currents, additional late responses are observed. Our results contribute towards efforts to define the mechanism of spinal cord stimulation. The minimally invasive recording technique we have developed provides data previously obtained only through microelectrode techniques in spinal cords of animals. Our observations also allow the development of systems that use neuronal recording in a feedback loop to control neurostimulation on a continuous basis and deliver more effective pain relief. This is one of numerous benefits that in vivo electrophysiological recording can bring to a broad range of neuromodulation therapies.
细分领域
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