查看“PD-闭环小组/睡眠电生理/The Neurophysiology of Sleep in Parkinson's Disease”的源代码

{{文章推荐|Reason=皮层和皮层下电生理是探究帕金森病患者睡眠障碍机制及睡眠调控策略的重要手段，该综述整理了帕金森病患者在不同睡眠分期下的睡眠障碍问题及相应的电生理表现，并讨论了通过靶向睡眠的DBS刺激调控运动及非运动症状的可行性。|Journal=Movement Disorders|PubYear=2021|DOI=10.1002/mds.28562|Category_=综述|Domain=睡眠电生理|RecomBy=张国坤|RecomGrp=PD-闭环小组|ReviewBy=於慧龄|Abstract=Sleep disturbances are among the most common nonmotor complications of Parkinson's disease (PD), can present in prodromal stages, and progress with advancing disease. In addition to being a symptom of neurodegeneration, sleep disturbances may also contribute to disease progression. Currently, limited options exist to modulate sleep disturbances in PD. Studying the neurophysiological changes that affect sleep in PD at the cortical and subcortical level may yield new insights into mechanisms for reversal of sleep disruption. In this article, we review cortical and subcortical recording studies of sleep in PD with a particular focus on dissecting reported electrophysiological changes. These studies show that slow-wave sleep and rapid eye movement sleep are both notably disrupted in PD. We further explore the impact of these electrophysiological changes and discuss the potential for targeting sleep via stimulation therapy to modify PD-related motor and nonmotor symptoms. © 2021 International Parkinson and Movement Disorder Society.|DetaialsDM=帕金森病-睡眠障碍-电生理特征|Citation_=38|CitationBy=/scholar?cites=18372185910465072204&amp;as_sdt=2005&amp;sciodt=0,5&amp;hl=en}}