Disruption of Cancer Cell Replication by Alternating Electric Fields
推荐理由
最早发现中频电场具有抑制肿瘤细胞有丝分裂的作用，并提出了电场可能的作用机制
| 文章简介 | |
|---|---|
| 期刊 | CANCER RESEARCH |
| 发表年份 | 2004 |
| DOI | 10.1158/0008-5472.CAN-04-0083 |
| 类型 | 研究性工作 |
| 领域 | 肿瘤治疗电场 |
| 引用量 | 860 |
| 推荐信息 | |
|---|---|
| 推荐人 | 杨鑫 |
| 审核 | 胡春华 |
| 推荐小组 | TTF小组 |
摘要
Low-intensity, intermediate-frequency (100–300 kHz), alternating electric fields, delivered by means of insulated electrodes, were found to have a profound inhibitory effect on the growth rate of a variety of human and rodent tumor cell lines (Patricia C, U-118, U-87, H-1299, MDA231, PC3, B16F1, F-98, C-6, RG2, and CT-26) and malignant tumors in animals. This effect, shown to be nonthermal, selectively affects dividing cells while quiescent cells are left intact. These fields act in two modes: arrest of cell proliferation and destruction of cells while undergoing division. Both effects are demonstrated when such fields are applied for 24 h to cells undergoing mitosis that is oriented roughly along the field direction. The first mode of action is manifested by interference with the proper formation of the mitotic spindle, whereas the second results in rapid disintegration of the dividing cells. Both effects, which are frequency dependent, are consistent with the computed directional forces exerted by these specific fields on charges and dipoles within the dividing cells. In vivo treatment of tumors in C57BL/6 and BALB/c mice (B16F1 and CT-26 syngeneic tumor models, respectively), resulted in significant slowing of tumor growth and extensive destruction of tumor cells within 3–6 days. These findings demonstrate the potential applicability of the described electric fields as a novel therapeutic modality for malignant tumors.
细分领域