Circuit Mechanisms of Parkinson’s Disease

推荐理由

文章讨论了PD的主要临床症状和相关的神经病理学，详细描述了基底节-丘脑皮质回路、PD相关回路功能障碍主要位点，介绍了PD研究的多尺度网络模型。文章综述了多种PD神经回路和症状的相关研究，为深入了解PD的基底节建模领域提供了良好的视野。

文章简介
期刊	Neuron
发表年份	2019
DOI	10.1016/j.neuron.2019.03.004
类型	综述
领域	计算神经科学
引用量	375

推荐信息
推荐人	樊钰
审核	於慧龄
推荐小组	PD-闭环小组

摘要

Parkinson's disease (PD) is a complex, multi-system neurodegenerative disorder. The second most common neurodegenerative disorder after Alzheimer's disease, it affects approximately 1% of adults over age 60. Diagnosis follows the development of one or more of the core motor features of the disease, including tremor, slowing of movement (bradykinesia), and rigidity. However, there are numerous other motor and nonmotor disease manifestations. Many PD symptoms result directly from neurodegeneration; others are driven by aberrant activity patterns in surviving neurons. This latter phenomenon, PD circuit dysfunction, is an area of intense study, as it likely underlies our ability to treat many disease symptoms in the face of (currently) irreversible neurodegeneration. This Review will discuss key clinical features of PD and their basis in neural circuit dysfunction. We will first review important disease symptoms and some of the responsible neuropathology. We will then describe the basal ganglia-thalamocortical circuit, the major locus of PD-related circuit dysfunction, and some of the models that have influenced its study. We will review PD-related changes in network activity, subdividing findings into those that touch on the rate, rhythm, or synchronization of neurons. Finally, we suggest some critical remaining questions for the field and areas for new developments.

细分领域

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