Basal ganglia engagement during REM sleep movements in Parkinson’s disease

推荐理由

该工作首次探究了帕金森病患者REM期肢体运动与GPi脑电特征变化（beta、gamma）的规律。通过这项工作增加了REM期电生理特征波动的认识，并且对REM期神经环路功能的假设进行了探讨，对REM期调控模式具有启发意义。

文章简介
期刊	npj Parkinson s Disease
发表年份	2022
DOI	10.1038/s41531-022-00382-z
类型	研究性工作
领域	睡眠电生理
引用量	4

推荐信息
推荐人	关凌霄
审核	於慧龄
推荐小组	PD-闭环小组

摘要

To elucidate the role of the basal ganglia during REM sleep movements in Parkinson’s disease (PD) we recorded pallidal neural activity from four PD patients. Unlike desynchronization commonly observed during wakeful movements, beta oscillations (13–35 Hz) synchronized during REM sleep movements; furthermore, high-frequency oscillations (150–350 Hz) synchronized during movement irrespective of sleep-wake states. Our results demonstrate differential engagement of the basal ganglia during REM sleep and awake movements.

细分领域

< | 帕金森病 | 睡眠 | REM期生物标志物研究