Basal ganglia beta oscillations during sleep underlie Parkinsonian insomnia
推荐理由
该研究比较了两只灵长动物在PD造模前后的自发睡眠活动及睡眠中的基底节电生理特征，发现NREM期的beta活动与失眠的严重程度相关并可能阻碍皮层慢波振荡活动的进行。该文章提供了从基底节分析PD睡眠障碍机制的新思路
| 文章简介 | |
|---|---|
| 期刊 | PNAS |
| 发表年份 | 2020 |
| DOI | 10.1073/pnas.2001560117 |
| 类型 | 研究性工作 |
| 领域 | 睡眠电生理 |
| 引用量 | 28 |
| 推荐信息 | |
|---|---|
| 推荐人 | 张国坤 |
| 审核 | 於慧龄 |
| 推荐小组 | PD-闭环小组 |
摘要
Sleep disorders are among the most debilitating comorbidities of Parkinson’s disease (PD) and affect the majority of patients. Of these, the most common is insomnia, the difficulty to initiate and maintain sleep. The degree of insomnia correlates with PD severity and it responds to treatments that decrease pathological basal ganglia (BG) beta oscillations (10–17 Hz in primates), suggesting that beta activity in the BG may contribute to insomnia. We used multiple electrodes to record BG spiking and field potentials during normal sleep and in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism in nonhuman primates. MPTP intoxication resulted in severe insomnia with delayed sleep onset, sleep fragmentation, and increased wakefulness. Insomnia was accompanied by the onset of nonrapid eye movement (NREM) sleep beta oscillations that were synchronized across the BG and cerebral cortex. The BG beta oscillatory activity was associated with a decrease in slow oscillations (0.1–2 Hz) throughout the cortex, and spontaneous awakenings were preceded by an increase in BG beta activity and cortico-BG beta coherence. Finally, the increase in beta oscillations in the basal ganglia during sleep paralleled decreased NREM sleep, increased wakefulness, and more frequent awakenings. These results identify NREM sleep beta oscillation in the BG as a neural correlate of PD insomnia and suggest a mechanism by which this disorder could emerge.
细分领域